Coupling of Electrical and Metabolic Activity During Epileptiform Discharges
نویسندگان
چکیده
منابع مشابه
Interneurons contribute to the hemodynamic/metabolic response to epileptiform discharges.
Interpretation of hemodynamic responses in epilepsy is hampered by an incomplete understanding of the underlying neurovascular coupling, especially the contributions of excitation and inhibition. We made simultaneous multimodal recordings of local field potentials (LFPs), firing of individual neurons, blood flow, and oxygen level in the somatosensory cortex of anesthetized rats. Epileptiform di...
متن کاملIn vivo neuronal firing patterns during human epileptiform discharges replicated by electrical stimulation
OBJECTIVE To describe neuronal firing patterns observed during human spontaneous interictal epileptiform discharges (IEDs) and responses to single pulse electrical stimulation (SPES). METHODS Activity of single neurons was recorded during IEDs and after SPES in 11 consecutive patients assessed with depth EEG electrodes and attached microelectrodes. RESULTS A total of 66 neurons were recorde...
متن کاملInterictal Epileptiform Discharges
EEG remains the primary technique in the diagnosis, characterization, and localization of partial seizures. This review examines the significance and character of interictal epileptiform abnormailites, periodic lateralized epileptiform discharges, and ictal patterns in patients with partial epilepsy. Interictal epileptiform discharges are common and assist in the diagnosis and localization of p...
متن کاملInterictal Epileptiform Discharges Might Be More Likely During Particular Phases of Brain Activity
Many epilepsy patients exhibit intermittent abnormal brain activity, evident as abnormal electrical events on electroencephalography (EEG), at times when they are not having a seizure. Despite the ease with which these so-called interictal epileptiform discharges (IEDs) can be detected, and a reasonable understanding of the physiological processes occurring during the IED (1), the effect of IED...
متن کاملInterictal epileptiform discharges do not change before seizures during sleep.
PURPOSE Whether interictal epileptiform discharges (IEDs) increase, decrease, or are unchanged before epileptic seizures has implications for the pathophysiology of epilepsy. Prior studies relating IEDs and seizures have not demonstrated a change in IEDs before seizures. However, they have not controlled for changes in the depth of sleep. Our objective was to test the hypothesis that IEDs are r...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2002
ISSN: 0013-9580,1528-1167
DOI: 10.1046/j.1528-1157.43.s.5.15.x